Euphonia Strathom has gone missing under bizarre circumstances. Her apartment is painted in occult symbols. A spellbook in her handwriting is the only clue. With no obvious signs of foul play, the local police have closed the case.

What should have been an easy case has thrown Private Detective Jackson Lee West into the bizarre and esoteric city of Arkham, Massachusetts. Out of his depth, he enlists the aid of Dr. Mystery Whateley, professor of Occult Sciences at the local Miskatonic University. With her help, leads begin to turn up pointing the team to something much more strange and sinister than a simple case of an adult choosing to disappear. Something horrifying is hunting them from the Shadows.West and Whateley may be the only thing standing between a dangerous cult and the end of the world.