When Elias Bouquet's suburban community has an outbreak of the bizarre and unexplained disease, AHS - Acquired Hypersexuality Syndrome - he has cause to be excited. Most people jump at the chance to be more attractive (albeit more libidinous) versions of themselves. However, it quickly becomes clear that Elias doesn't have a typical case of AHS. In fact, he appears to be turning into a she. How will Elias deal with the changes, and will he ever be able to have some semblance of a normal life afterward?