Death by Ex-Girlfriend returns in a new arc, Dawn and Dusk. Dawn and Dusk continues the tale of Osamu Ashikaga, his ex-girlfriends, and the many friends they've made along the way. It's especially a story of Isabella Bailey. As she continues to regain her strength and her ability to walk, her world is torn apart by a different problem. All of her seemingly innocent stomach aches throughout the past two years were anything but. They were the warning signs of a looming illness.

Faced with her own mortality, Isabella and her friends hope for the best and prepare for the worst.

Dawn and Dusk is a bittersweet tale of friendship, love, memories, and tragedy. Just as this happy family of former lovers and friends came together, there must also be a time when one leaves, and sometimes, there's nothing you can do to stop it.