Deviants are the offshoots of humanity ranging from the mystic Arcane, to the unnatural Deadmen, or even the unstable Anomalies. Regardless of what Deviation a person may possess, all Deviants are considered dangerous by the public. Despite these views, most Deviants are just trying to live whatever life they can, just like everybody else.

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Deviant's Masquerade is meant as an urban-fantasy/ superhero Anthology with each episode being a multi-chapter arc, following a different set of characters all existing in the same world(s).